On one side of the face, Horner syndrome affects the eye and surrounding area. A stroke, tumor, injury, or infection can cause Horner syndrome, which occurs when the sympathetic nerves controlling pupil size, eyelid movement, and sweating are damaged. Horner syndrome can also be inherited or present from birth. The syndrome is not life-threatening, but it can indicate a serious underlying problem that needs medical attention.
Horner syndrome occurs when the pathway of the sympathetic nerves that connect the brain to the eye and the face is interrupted. The interruption can happen at different levels of the pathway, depending on the cause. Some of the possible causes of Horner syndrome are:
Damage to the brainstem, which is the part of the brain that connects to the spinal cord. This can be caused by a stroke, a tumor, an injury, or an infection.
Damage to the cervical spine, which is the part of the spinal cord that runs through the neck. This can be caused by a trauma, a surgery, a tumor, or a disease that affects the spinal cord, such as multiple sclerosis.
Damage to the carotid artery, which is the main blood vessel that supplies blood to the head and the neck. This can be caused by a tear, a blockage, or a narrowing of the artery, which can reduce the blood flow to the brain and the nerves.
Damage to the chest or the neck, which can affect the nerves that run along the side of the neck and the upper chest. This can be caused by a lung cancer, a thyroid cancer, a lymphoma, a surgery, or a radiation therapy.
Congenital or inherited factors, which can affect the development of the sympathetic nerves before or after birth. This can be caused by a genetic mutation, a chromosomal abnormality, or a birth trauma.
The symptoms of Horner syndrome usually affect only one side of the face. They include:
A small pupil (miosis) that does not dilate well in the dark or in response to eye drops.
A droopy upper eyelid (ptosis) that may cover part of the pupil.
A raised lower eyelid (reverse ptosis) that may reduce the size of the eye opening.
A lack of sweating (anhidrosis) or flushing on the affected side of the face.
A sunken appearance of the eye (enophthalmos) due to the loss of muscle tone around the eye.
A change in the color of the iris (heterochromia) in some cases, especially in children. The affected eye may be lighter or darker than the other eye.
When Horner syndrome occurs in bright light, cold weather, or when feeling emotionally ill, symptoms may vary in severity and may be more noticeable. Depending on the cause of the nerve damage, other signs or symptoms may also accompany the symptoms.
Medical history, physical examination, and some tests are used to diagnose Horner syndrome. In addition to asking about the onset, duration, and progression of the symptoms, the doctor will ask about any potential risk factors, such as trauma, surgery, infections, or family history. Horner syndrome is also characterized by pupil size, eyelid position, and sweating pattern, which the doctor will look for in the eyes and face.
The doctor may also order some tests to confirm the diagnosis and to identify the cause of Horner syndrome. Some of the tests that may be used are:
In an eye drop test, different types of eye drops are applied to the affected eye and the pupil size and position of the eyelids are observed. By performing this test, you can determine the extent of nerve damage and rule out other conditions that can cause similar symptoms, such as glaucoma or migraine.
An X-ray, an MRI, or a CT scan can provide detailed images of the brain, the spinal cord, the blood vessels, and the chest and detect any abnormalities that can cause Horner syndrome, such as a stroke, a tumor, or a wound.
Tests that measure the levels of hormones, enzymes, or antibodies in the blood, which can help diagnose conditions such as diabetes, thyroid disorders, or autoimmune diseases that can cause Horner syndrome.
The treatment of Horner syndrome depends on the cause, the severity, and the symptoms of the condition. Some of the possible treatments for Horner syndrome include: The main goal is to address the underlying problem that is causing nerve damage and to prevent further complications or damage.
Medications, which can help treat some of the causes or the symptoms of Horner syndrome, such as antibiotics for infections, anticoagulants for blood clots, or painkillers for headaches.
Surgery, which can help repair or remove some of the sources of nerve damage, such as a tumor, a blood vessel, or a bone fragment. Surgery can also help correct some of the cosmetic effects of Horner syndrome, such as a droopy eyelid or a small pupil.
Radiation therapy or chemotherapy, which can help shrink or destroy some of the cancers that can cause Horner syndrome, such as a lung cancer, a thyroid cancer, or a lymphoma.
Physical therapy or occupational therapy, which can help improve the function and the appearance of the eye and the face, as well as the quality of life of the person with Horner syndrome. These therapies can include exercises, massage, heat, or electrical stimulation.
There is no specific way to prevent Horner syndrome, as it is a rare and complex condition that can have many different causes. However, some general measures that may help reduce the risk or the severity of Horner syndrome are:
When the family has a history of Horner syndrome or other neurological or vascular disorders, it's important to get regular medical checks and screenings. If the sympathetic nerves are affected by high blood pressure, high cholesterol, diabetes, or thyroid disorders, this can help detect and treat them.
The prevention or reduction of stroke, tumors, injuries, or infections that can cause Horner syndrome can be achieved by avoiding or limiting the exposure to harmful substances.
A doctor's instructions and prescribed medications must be followed, particularly if a condition is diagnosed that can cause Horner syndrome, such as diabetes, thyroid disorder, or autoimmune disease. As a result, the condition can be controlled or managed and further damage to the sympathetic nerves prevented.
Horner syndrome symptoms include a small pupil, droopy eyelid, and lack of sweating on one side of the face, so seek immediate medical attention. By doing so, Horner syndrome can be diagnosed and treated properly and any life-threatening consequences can be prevented.
