Fungal infections such as cryptococcisis can affect different parts of the body, including the brain and lungs. There are two types of fungi responsible for this disease: Cryptococcus neoformans and Cryptococcus gattii. These fungi can be found in the environment, in soil, trees, and bird droppings. It is possible to be infected by breathing the fungal spores.
Those with weakened immune systems, such as those with HIV/AIDS, cancer, organ transplants, or diabetes, may suffer serious complications from cryptococcosis. However, it can also affect healthy people, especially those living in areas where C. gattii is common, including the Pacific Northwest of the U.S. and Canada.
Cryptococcosis is caused by exposure to Cryptococcus fungi in the environment. The most common sources of infection are:
Soil contaminated with bird droppings, especially from pigeons and bats.
Decaying wood and plant material, especially from eucalyptus trees and other tropical and subtropical plants.
Inhalation of dust or aerosols that contain the fungal spores.
The risk of getting cryptococcosis depends on several factors, such as:
The amount and duration of exposure to the fungi.
The type and strain of the fungi. C. gattii is more likely to cause infection in healthy people than C. neoformans.
The immune status of the person. People with weakened immune systems are more vulnerable to infection and complications.
The geographic location of the person. Cryptococcosis is more common in certain regions of the world, such as Africa, Asia, Australia, and the Pacific Northwest of the U.S. and Canada.
The symptoms of cryptococcosis vary depending on the part of the body that is affected. The most common forms of cryptococcosis are:
Symptoms of pulmonary cryptococcosis include coughing, chest pain, shortness of breath, fever, and weight loss. Some people may not have any symptoms or have mild symptoms that resemble pneumonia or tuberculosis.
As a result of cryptococcal meningitis, the brain and spinal cord membranes become infected. Symptoms include headache, fever, neck stiffness, nausea, vomiting, confusion, seizures, and vision problems. This is the most serious and life-threatening form of cryptococcosis and requires immediate medical treatment.
A disease known as disseminated cryptococcosis occurs when the infection spreads to other parts of the body, including the skin, bones, joints, liver, spleen, and eyes. There can be skin rashes, sores, bumps, blisters, bone pain, joint swelling, abdominal pain, and inflammation of the eyes.
The diagnosis of cryptococcosis is based on the following tests:
Blood tests: These can detect the presence of antibodies or antigens to the fungi in the blood. They can also measure the level of inflammation and infection in the body.
Culture tests: These can isolate and identify the type and strain of the fungi from samples of blood, urine, sputum, cerebrospinal fluid, or tissue.
Imaging tests: These can show the extent and location of the infection in the lungs, brain, or other organs. They include chest X-rays, CT scans, MRI scans, and ultrasound.
Biopsy tests: These can examine the tissue samples from the affected organs under a microscope and confirm the diagnosis of cryptococcosis.
The treatment of cryptococcosis depends on the severity and location of the infection, the type and strain of the fungi, and the immune status of the person. The main goals of treatment are to:
Kill the fungi and clear the infection.
Reduce the inflammation and pressure in the brain and spinal cord.
Prevent the recurrence or relapse of the infection.
The treatment of cryptococcosis usually involves the following steps:
Antifungal medications: These are drugs that kill or stop the growth of the fungi. They are given orally or intravenously, depending on the type and stage of the infection. Fluconazole, amphotericin B, and flucytosine are the most common antifungal medications used for cryptococcosis. Depending on the individual, the treatment lasts for several weeks or months, depending on the duration and dosage of the treatment.
Usually in conjunction with antifungal medications, steroids reduce inflammation and swelling in the brain and spinal cord. The most common steroid medication used for cryptococcosis is dexamethasone, which is given intravenously or orally. Treatment duration and dosage depend on individual circumstances, but it usually lasts for a few days to weeks.
Surgery: This procedure removes excess fluid from the brain and spinal cord by inserting a needle or tube into the skull or the spine and draining the cerebrospinal fluid. It is usually done in cases of severe cryptococcal meningitis that are unresponsive to medical treatment.
The prevention of cryptococcosis involves the following measures:
It is important to avoid contact with fungi in the environment, especially in areas where they are known to be prevalent. This includes wearing protective masks, gloves, and clothing when handling soil, wood, or bird droppings, and avoiding contact with sick or dead birds.
Taking prophylactic antifungal medications, especially for people with weakened immune systems or are at high risk of infection, such as HIV/AIDS, cancer, organ transplants, or diabetes. Fluconazole is the most commonly used prophylactic antifungal medication for cryptococcosis. Prevention lasts usually for a few months to years, depending on the individual case.
Getting regular check-ups and tests, especially for people who have been diagnosed with cryptococcosis or are at high risk of infection. During this process, blood and cerebrospinal fluid levels of fungi, inflammation markers, and imaging tests are monitored to detect recurrence or relapse of infection.
