Photo of Preston Holifield

Preston Holifield, DNP

Concierge Family Medicine nurse practitioner, Cape Girardeau, MO

Guardian Primary Care

Preston Holifield is a Concierge Family Medicine nurse practitioner who leads Guardian Primary Care in Cape Girardeau, Missouri.

2441 Myra Dr, Cape Girardeau, MO 63703
At a glance
Practice model
Insurance plus a direct care rate
Insurance
In network with most major commercial insurances, Medicare and Medicaid
Certification
Family nurse practitioner, AANP

Facts on this page last checked October 2026. How we check doctors

About Preston Holifield

Holifield holds a Doctor of Nursing Practice degree and the APRN and FNP-C credentials. Holifield is certified as a family nurse practitioner by the American Academy of Nurse Practitioners. Holifield is licensed by the Missouri State Board of Nursing.

Holifield opened his own practice, Guardian Primary Care. Direct care has no limit on visits, and sick visits are same or next day. Holifield believes in evidence-based, guideline-directed healthcare.

Years of nursing experience help Holifield look for the root cause of patients' health concerns. Holifield wants patients to feel the clinic is a safe place to speak freely and to heal in mind, body and spirit. Holifield also created PrestonNP, a health education platform with YouTube videos.

Membership and fees

Guardian Primary Care is in network with most major commercial insurances, Medicare and Medicaid.

It also offers a published monthly direct care rate.

Direct care has no limit on visits.

Licenses and credentials

Degree
Doctor of Nursing Practice (DNP)
Other certification
APRN, FNP-C (certified through the American Academy of Nurse Practitioners)
License
Missouri Verify on Nursys
NPI
1982397436

Hospital and practice affiliations

Leads Guardian Primary Care

Location

2441 Myra Dr, Cape Girardeau, MO 63703
Guardian Primary Care practice page
Directions

Recognition and research

Media and books

Created PrestonNP, a health education platform with YouTube videos.

Patient reviews

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Questions patients ask

Is Preston Holifield a doctor, and where is Holifield licensed?

Holifield is a nurse practitioner, not a physician. Holifield is licensed by the Missouri State Board of Nursing.

Does Guardian Primary Care take insurance?

The practice is in network with most major commercial insurances, Medicare and Medicaid. It also offers a published monthly direct care rate.

Where is Holifield's office?

Holifield leads Guardian Primary Care in Cape Girardeau, Missouri.

Does Guardian Primary Care offer telehealth?

Telehealth visits are offered.

How does direct care work at Guardian Primary Care?

Direct care has no limit on visits. Sick visits are same or next day.

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